Individual variation in pain response

Individual differences in sensory experiences are of profound importance in the treatment of pain. Subjective ratings are essential for the diagnosis and treatment of pain, but profound individual differences in sensitivity complicate treatment. The study of individual differences in pain has only recently been a topic of focused examination. Historically, reliance on subjective reports dampened enthusiasm for such lines of investigation, but the increasing confidence in psychophysical assessment of pain, in combination with increasing capability to explore genetic contributions to pain, has led to a growth in the output of this aspect of  pain research. The contributions of functional imaging studies to the determination of the neural mechanisms supporting cognitive and psychological modulation of pain has opened new realms for the investigation of individual differences. However, the development of a full understanding of individual differences in pain remains challenging, due to the myriad of genetic, environmental, psychological, and cognitive variables that can shape such differences.

  • Geriatric
  • Genetic makeup
  • Pediatric
  • Cultural background
  • Pain Genetics

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