Marieke H J van den Beuken-van Everdingen
Maastricht University, Netherlands
Title: Update on prevalence of pain in patients with cancer: Systematic review and meta-analysis
Biography
Biography: Marieke H J van den Beuken-van Everdingen
Abstract
Context: Cancer pain has a severe impact on quality of life and is associated with numerous psychosocial responses. Recent studies suggest that treatment of cancer pain has improved during the last decade.
Objectives: The aim of this review was to examine the present status of pain prevalence and pain severity in patients with cancer.
Methods: A systematic search of the literature published between September 2005 and January 2014 was performed using the databases of PubMed, Medline, EMBASE, CINAHL, and Cochrane. Articles in English or Dutch that reported on the prevalence of cancer pain in an adult cancer population were included. Titles and abstracts were screened by two authors independently, after which full texts were evaluated and assessed on methodological quality. Study details and pain characteristics were extracted from the articles with adequate study quality. Prevalence rates were pooled with meta-analysis; meta-regression was performed to explore determinants of pain prevalence.
Results: Out of 4117 titles, 122 studies were selected for the meta-analyses on pain (117 studies, n=63533) and pain severity (52 studies, n=32261). Pain prevalence rates were 39.3% after curative treatment; 55.0% during anti-cancer treatment; 66.4% in advanced, metastatic or terminal disease. Moderate to severe pain (NRS ≥5) was reported by 38.0% of all patients.
Conclusion: Despite increased attention for the assessment and management, pain continues to be a prevalent symptom in patients with cancer. In the upcoming decade we need to overcome barriers towards effective pain treatment and develop and implement interventions to optimally manage pain in patients with cancer.